A collaborative work of Tanushree Gupta and Andrey Klymchenko with Michael Ryckelynck, Janine KEHRLI and Roger Cubí Piqué from UPR9002-IBMC, Strasbourg, resulted in oShark, a chemically modified light-up aptamer designed to resist degradation in complex biological environments, which is now published in the Journal of the American Chemical Society…
Photodynamic therapy (PDT) is a promising strategy against head and neck squamous cell carcinoma (HNSCC). In this study led by Chloé Thibaudeau et Alain Jung from the ONKO3T team, in collaboration with Professor Gilles GASSER, they investigated how different ruthenium(II)-based photosensitizers (PS) influence tumor cell death and immune response. …
We are pleased to announce the publication of a study conducted by Nario TOMISHIGE, Yves MELY, and Toshihide KOBAYASHI on how the HIV-1 Gag protein reorganizes lipids in the host plasma membrane. HIV-1 is enveloped in a membrane derived from the host cell, which is notably enriched in specific lipids such as sphingomyelin (SM) and cholesterol…
New publication: Decoding the blinking of fluorescent polymer nanoparticles Interdisciplinary collaboration between chemists and physicists from Andrey Klymchenko's team— Deep Sekhar Biswas, Benjamin Boglio and Pascal Didier — and theorists from the University of Bologna: Giacomo Fanciullo, Silvia Bordoni and Ivan Rivalta, has made it possible to…
Read Marion Riegert's popular science article published in the University of Strasbourg's Savoir(s) magazine, which explains the role of UHRF1 in the transmission of epigenetic memory in cells. Link : Le mécanisme de la protéine UHRF1 mis en lumière | Savoirs - Le quotidien de l’Université de Strasbourg
Lipid nanoemulsions (NEs) are promising eco-friendly nanocarriers for diagnostic and therapeutic applications. However, functionalizing them with biomolecules, such as antibodies, remains difficult due to the liquid nature of their core. In this study, Andrey Klymchenko's team, with Valeria Jose BOIDE-TRUJILLO as the first author and in…
The RISEst and Alsace France-BioImaging Node platforms are organizing a new training session entitled: "Introduction to bio-image processing and analysis with Fiji/ImageJ" October 30–31, 2025 – Faculty of Pharmacy, Illkirch This free training course, conducted in English, is intended for all academic users of RISEst platforms: students, engineers,…
This year, our laboratory is actively participating in the Science Festival through two major events: Lingolsheim Science Village Léa DENECHERE and Charlène D'ANCONA from the Biophonics of Molecular and Cellular Interactions team will lead the interactive workshop “The World of RNA and Aptamers” (in virtual reality) in collaboration with…
The DNA-PAINT (Point Accumulation for Imaging in Nanoscale Topography) technique exploits transient hybridization of DNA strands to achieve nanometric resolution. Although effective, it remains limited in its standard form by background noise generated by unbound strands and slow image acquisition. In a new study, a project initiated and led by Yv…
Dipanjan Mukherjee and members of the BIMC team led by Yves Mély, along with their collaborators from the Instituto de Química Física Blas Cabrera (IQF-CSIC), the Université de SanDiego, the Istituto Biostrutture eBioimmagini and the Università Di Siena have just published a new article in the international journal Nucleic Acids Research. This…
The aim of the Laboratory of Bioimaging and Pathology is to use multidisciplinary (biology/chemistry/physics) and multi-scale (from molecule to patient) approaches to study, at both fundamental and applied levels, the properties and roles of a limited number of key biomolecules involved in various pathological processes. Our approach is to develop new therapeutic and diagnostic approaches in oncology and microbiology based on information obtained at the fundamental level. A key feature of the unit is the parallel development and characterisation of innovative fluorescence-based tools, methods and techniques to answer these questions. This multidisciplinary approach, which combines the development of innovative fluorescence and imaging tools to address biological questions, is unique in the French scientific landscape.
A collaborative work of Tanushree Gupta and Andrey Klymchenko with Michael Ryckelynck, Janine KEHRLI and Roger Cubí Piqué from UPR9002-IBMC,…
Photodynamic therapy (PDT) is a promising strategy against head and neck squamous cell carcinoma (HNSCC). In this study led by Chloé Thibaudeau et…
We are pleased to announce the publication of a study conducted by Nario TOMISHIGE, Yves MELY, and Toshihide KOBAYASHI on how the HIV-1 Gag protein…
New publication: Decoding the blinking of fluorescent polymer nanoparticles Interdisciplinary collaboration between chemists and physicists from And…
Read Marion Riegert's popular science article published in the University of Strasbourg's Savoir(s) magazine, which explains the role of UHRF1 in the…
Lipid nanoemulsions (NEs) are promising eco-friendly nanocarriers for diagnostic and therapeutic applications. However, functionalizing them with…
The RISEst and Alsace France-BioImaging Node platforms are organizing a new training session entitled: "Introduction to bio-image processing and…
This year, our laboratory is actively participating in the Science Festival through two major events: Lingolsheim Science Village Léa…
The DNA-PAINT (Point Accumulation for Imaging in Nanoscale Topography) technique exploits transient hybridization of DNA strands to achieve nanometric…
Dipanjan Mukherjee and members of the BIMC team led by Yves Mély, along with their collaborators from the Instituto de Química Física Blas Cabrera…
We are pleased to announce the publication of a scientific article co-authored by several members of the BIMC team: Ludovic Richert, Patrice Rassam,…
We are pleased to announce the publication in the scientific journal Nanoscale (Royal Society of Chemistry) of work carried out by Paraskevi Gaki from…
Olha Tkach and members of the Biophotonics of Molecular and Cellular Interactions team led by Yves Mély, , in collaboration with the Instituto de…
Andrey Klymchenko, Pascal Didier from the Photoactive Materials and Bioimaging team, and Deep Sekhar Biswas ( past member) have co-authored a review…
A new study, coordinated by Drs. hibaut Wolf and Benoît Lhermitte (CHRU de Strasbourg), (Strasbourg University Hospital), has just been published in t…
New mapping revolutionizes glioblastoma management
We are proud to announce the publication of the work of Nathan Aknine, Rémi Pelletier and Andrey Klymchenko from the Photoactive Materials and…
Klymchenko team, in collaboration with BrightSens Diagnostics and teams of Pfeiffer (UPR9002-CNRS ARN) and Fafi- Kremer (HUS), has developed a…
New probes for imaging lipid droplets Nathan Aknine, a PhD student in the Photoactive Materials and Bioimaging team, recently published a paper with…
UpConverting NanoParticles (UCNPs) are capable of emitting visible light very efficiently after excitation by infrared light. UCNPs’ Anti-Stockes…
Human immunodeficiency virus type 1 (HIV-1) causes AIDS and is a member of envelope viruses in which virus particles are surrounded by a lipid…
Photo-convertible fluorescent probes are able to change their emission color upon light irradiation. This phenomenon is advantageously used in…
Kinetics of protein-assisted nucleic acid interconversion monitored by transient time resolved fluorescence in microfluidic droplets Interconversio…
Intermolecular dark resonance energy transfer (DRET): upgrading fluorogenic DNA sensing FRET sensitivity is usually limited by the spectral…
Fundamental photophysics of isomorphic and expanded fluorescent nucleoside analogues Isomorphic and expanded fluorescent nucleoside analogues are…
Under the title “What makes thienoguanosine an outstanding fluorescent DNA probe?”, the work of the Laboratory of Bioimaging and Pathologies (CNRS /…
With the title in French « Les photons associent leur énergie pour améliorer l’imagerie », collective data from the Institut pluridisciplinaire Hubert…
The group of A. Klymchenko “Nanochemistry and Bioimaging” developed DNA-functionalized fluorescent polymeric nanoparticles for amplified detection of…
