Maeva Martin, first author—under the supervision of Laurence Choulier - and co-directed by Julie Helms - along with Marine Tschirhart, Cyril Auger, and Florence Toti from the UMR 1260 Regenerative Nanomedicine unit (University of Strasbourg/Inserm), present a new review published in Annals of Intensive Care (Elsevier). This review highlights the…
We would like to extend our warmest congratulations to Pankhi Singh, who defended her thesis under the supervision of Prof. Yves Mély in the Biophotonics of Molecular and Cellular Interactions team. Her work focused on the study of G-quadruplexes, remarkable nucleic acid structures, and their interactions with proteins. This project, at the…
The PIQ-QuESt platform in collaboration with PicoQuant and OPTON LASER internationalinvites you to discover Luminosa, an innovative confocal microscope dedicated to simple, fast, and reliable measurements of single molecules. You will be able to • Explore the latest advances in low-light confocal imaging and color/lifetime multiplexing. Discov…
We are pleased to invite you to our next seminar entitled: « Chemical modulation of G-quadruplex (G4) structures in human cells» by David Monchaud. After a PhD in supramolecular chemistry in Geneva and completing two postdoctoral fellowships in medicinal chemistry and chemical biology in Paris, our speaker, Director of Research at the CNRS, made…
A Scientific Career Dedicated to Innovation in Biomedical Imaging We are proud to announce Rémi Pelletier’s success in the CNRS competition and his recruitment as a research engineer. After actively contributing to the laboratory’s work as a postdoctoral researcher, Rémi now continues his commitment within our team with a permanent position. His…
Rémi Pelletier, Anila Hoskere Ashoka and Andrey Klymchenko, de l'équipe Matériaux photoactifs et bioimagerie, from the Photoactive Materials and Bioimaging team, have developed fluorescent polymer nanofibers that act as multiplexed ratiometric sensors for pH and oxygen, two key parameters in the wound healing process. These sensors are based on …
A collaborative work of Tanushree Gupta and Andrey Klymchenko with Michael Ryckelynck, Janine KEHRLI and Roger Cubí Piqué from UPR9002-IBMC, Strasbourg, resulted in oShark, a chemically modified light-up aptamer designed to resist degradation in complex biological environments, which is now published in the Journal of the American Chemical Society…
Photodynamic therapy (PDT) is a promising strategy against head and neck squamous cell carcinoma (HNSCC). In this study led by Chloé Thibaudeau et Alain Jung from the ONKO3T team, in collaboration with Professor Gilles GASSER, they investigated how different ruthenium(II)-based photosensitizers (PS) influence tumor cell death and immune response. …
We are pleased to announce the publication of a study conducted by Nario TOMISHIGE, Yves MELY, and Toshihide KOBAYASHI on how the HIV-1 Gag protein reorganizes lipids in the host plasma membrane. HIV-1 is enveloped in a membrane derived from the host cell, which is notably enriched in specific lipids such as sphingomyelin (SM) and cholesterol…
New publication: Decoding the blinking of fluorescent polymer nanoparticles Interdisciplinary collaboration between chemists and physicists from Andrey Klymchenko's team— Deep Sekhar Biswas, Benjamin Boglio and Pascal Didier — and theorists from the University of Bologna: Giacomo Fanciullo, Silvia Bordoni and Ivan Rivalta, has made it possible to…
The aim of the Laboratory of Bioimaging and Pathology is to use multidisciplinary (biology/chemistry/physics) and multi-scale (from molecule to patient) approaches to study, at both fundamental and applied levels, the properties and roles of a limited number of key biomolecules involved in various pathological processes. Our approach is to develop new therapeutic and diagnostic approaches in oncology and microbiology based on information obtained at the fundamental level. A key feature of the unit is the parallel development and characterisation of innovative fluorescence-based tools, methods and techniques to answer these questions. This multidisciplinary approach, which combines the development of innovative fluorescence and imaging tools to address biological questions, is unique in the French scientific landscape.
Maeva Martin, first author—under the supervision of Laurence Choulier - and co-directed by Julie Helms - along with Marine Tschirhart, Cyril Auger,…
We would like to extend our warmest congratulations to Pankhi Singh, who defended her thesis under the supervision of Prof. Yves Mély in the…
The PIQ-QuESt platform in collaboration with PicoQuant and OPTON LASER internationalinvites you to discover Luminosa, an innovative confocal…
We are pleased to invite you to our next seminar entitled: « Chemical modulation of G-quadruplex (G4) structures in human cells» by David Monchaud. …
A Scientific Career Dedicated to Innovation in Biomedical Imaging We are proud to announce Rémi Pelletier’s success in the CNRS competition and his…
Rémi Pelletier, Anila Hoskere Ashoka and Andrey Klymchenko, de l'équipe Matériaux photoactifs et bioimagerie, from the Photoactive Materials and…
Bohdan successfully defended his thesis, which was jointly supervised by Andrey Klymchenko's team and Nobel Prize winner Professor Jean-Marie Lehn. …
A collaborative work of Tanushree Gupta and Andrey Klymchenko with Michael Ryckelynck, Janine KEHRLI and Roger Cubí Piqué from UPR9002-IBMC,…
Photodynamic therapy (PDT) is a promising strategy against head and neck squamous cell carcinoma (HNSCC). In this study led by Chloé Thibaudeau et…
We are pleased to announce the publication of a study conducted by Nario TOMISHIGE, Yves MELY, and Toshihide KOBAYASHI on how the HIV-1 Gag protein…
New publication: Decoding the blinking of fluorescent polymer nanoparticles Interdisciplinary collaboration between chemists and physicists from And…
Read Marion Riegert's popular science article published in the University of Strasbourg's Savoir(s) magazine, which explains the role of UHRF1 in the…
Lipid nanoemulsions (NEs) are promising eco-friendly nanocarriers for diagnostic and therapeutic applications. However, functionalizing them with…
The RISEst and Alsace France-BioImaging Node platforms are organizing a new training session entitled: "Introduction to bio-image processing and…
This year, our laboratory is actively participating in the Science Festival through two major events: Lingolsheim Science Village Léa…
The DNA-PAINT (Point Accumulation for Imaging in Nanoscale Topography) technique exploits transient hybridization of DNA strands to achieve nanometric…
New mapping revolutionizes glioblastoma management
We are proud to announce the publication of the work of Nathan Aknine, Rémi Pelletier and Andrey Klymchenko from the Photoactive Materials and…
Klymchenko team, in collaboration with BrightSens Diagnostics and teams of Pfeiffer (UPR9002-CNRS ARN) and Fafi- Kremer (HUS), has developed a…
New probes for imaging lipid droplets Nathan Aknine, a PhD student in the Photoactive Materials and Bioimaging team, recently published a paper with…
UpConverting NanoParticles (UCNPs) are capable of emitting visible light very efficiently after excitation by infrared light. UCNPs’ Anti-Stockes…
Human immunodeficiency virus type 1 (HIV-1) causes AIDS and is a member of envelope viruses in which virus particles are surrounded by a lipid…
Photo-convertible fluorescent probes are able to change their emission color upon light irradiation. This phenomenon is advantageously used in…
Kinetics of protein-assisted nucleic acid interconversion monitored by transient time resolved fluorescence in microfluidic droplets Interconversio…
Intermolecular dark resonance energy transfer (DRET): upgrading fluorogenic DNA sensing FRET sensitivity is usually limited by the spectral…
Fundamental photophysics of isomorphic and expanded fluorescent nucleoside analogues Isomorphic and expanded fluorescent nucleoside analogues are…
Under the title “What makes thienoguanosine an outstanding fluorescent DNA probe?”, the work of the Laboratory of Bioimaging and Pathologies (CNRS /…
With the title in French « Les photons associent leur énergie pour améliorer l’imagerie », collective data from the Institut pluridisciplinaire Hubert…
The group of A. Klymchenko “Nanochemistry and Bioimaging” developed DNA-functionalized fluorescent polymeric nanoparticles for amplified detection of…
