The OnKO•3T team is pleased to announce the publication of a comprehensive review in the journal *Histology and Histopathology*, titled : "CDKN2A alterations in solid tumors: From biological mechanisms to clinical applications, with special emphasis on central nervous system tumors". The CDKN2A gene, a major tumor suppressor, plays a central role…
Yelyzaveta Denysieva and Dmytro Dziuba, together with Ludovic Richert and Yves Mély from the BIMC team and Julie Karpenko from the LIT, have recently published a study on the development of improved fluorescent probes for fluorescence lifetime imaging microscopy (FLIM). The team investigated BODIPY-based fluorescent molecular rotors, a class of…
On September 26, 2026, Strasbourg will be decked out in gold to highlight its commitment to the fight against pediatric cancers, as part of “Golden September,” the international awareness month.
The physiological role of lipid asymmetry in intracellular membranes remains poorly understood. However, this asymmetry plays a key role in many cellular processes, including membrane trafficking and autophagy. A new publication by Toshihide Kobayashi's group in the BIMC team, led by Yves Mély, demonstrates that sphingomyelin (SM), a lipid…
The OnKO • 3T team, led by Sophie Martin,is one of the 54 winners of the National Cancer Institute’s PLBIO 2026 grant!Through the PITEP project, the team will develop a human preclinical platform combining: patient-derived organoidstumor-on-chip technologies to identify promising photosensitizers, develop photoimmunotherapy strategies, overcome…
Avantika Kapoor under the supervision of Halina Anton and Pascal Didier from Andrey Klymchenko’s team, has published her paper, “Fluorescence-Based Microviscosity Mapping in Membraneless Organelles” in the journal ACS Chemical & Biomedical Imaging. The team developed an integrated strategy combining: A BODIPY-based molecular rotor, whose…
Active targeting of tumor cells relies on the use of ligands capable of specifically binding to receptors that are overexpressed on their surface, such as EGFR (epidermal growth factor receptor). Among these ligands, monoclonal antibodies and aptamers are promising tools for the targeted delivery of therapeutic molecules (chemotherapy agents,…
Sophie Martin, , head of the OnKO • 3T team, has received a national grant of €60,729 from the JetonsCancer Endowment Fund, an initiative led by Rotary France. This funding, which is entirely dedicated to research, will enable the purchase of a HUMIMIC Chip+ system, a state-of-the-art device for developing innovative “tumors-on-a-chip” models. A…
Elisa Bombarda, a member of the Biophotonics of Molecular and Cellular Interactions team led by Yves Mély, has been selected as a recipient of the IdEx – Research Support Fund 2026 call for proposal ! Her project, « Light from the dark: what the dark states of fluorophores can tell », was selected as part of the University of Strasbourg’s France…
Nanoparticles (NPs) play a key role in biological applications, such as bioimaging and biosensing. Their stealth properties—that is, their ability to avoid nonspecific interactions with biological environments—is essential to ensuring their stability and efficacy in vivo. Until now, polyethylene glycol (PEG) has been the gold standard for imparting…
The aim of the Laboratory of Bioimaging and Pathology is to use multidisciplinary (biology/chemistry/physics) and multi-scale (from molecule to patient) approaches to study, at both fundamental and applied levels, the properties and roles of a limited number of key biomolecules involved in various pathological processes. Our approach is to develop new therapeutic and diagnostic approaches in oncology and microbiology based on information obtained at the fundamental level. A key feature of the unit is the parallel development and characterisation of innovative fluorescence-based tools, methods and techniques to answer these questions. This multidisciplinary approach, which combines the development of innovative fluorescence and imaging tools to address biological questions, is unique in the French scientific landscape.
The OnKO•3T team is pleased to announce the publication of a comprehensive review in the journal *Histology and Histopathology*, titled : "CDKN2A…
Yelyzaveta Denysieva and Dmytro Dziuba, together with Ludovic Richert and Yves Mély from the BIMC team and Julie Karpenko from the LIT, have recently…
On September 26, 2026, Strasbourg will be decked out in gold to highlight its commitment to the fight against pediatric cancers, as part of “Golden…
The physiological role of lipid asymmetry in intracellular membranes remains poorly understood. However, this asymmetry plays a key role in many…
The OnKO • 3T team, led by Sophie Martin,is one of the 54 winners of the National Cancer Institute’s PLBIO 2026 grant!Through the PITEP project, the…
Avantika Kapoor under the supervision of Halina Anton and Pascal Didier from Andrey Klymchenko’s team, has published her paper, “Fluorescence-Based…
Active targeting of tumor cells relies on the use of ligands capable of specifically binding to receptors that are overexpressed on their surface,…
Sophie Martin, , head of the OnKO • 3T team, has received a national grant of €60,729 from the JetonsCancer Endowment Fund, an initiative led by Rota…
Elisa Bombarda, a member of the Biophotonics of Molecular and Cellular Interactions team led by Yves Mély, has been selected as a recipient of the IdE…
Nanoparticles (NPs) play a key role in biological applications, such as bioimaging and biosensing. Their stealth properties—that is, their ability to…
Strasbourg, May 21 and 22, 2026 – Our laboratory made a significant impact at the 2026 Illkirch Campus Days (JCI) with exceptional participation and…
The team led by Prof. Yves MELY, with Pankhi Singh and Dipanjan Mukherjee as first authors, has just published a major study in the field of…
Neurotransmitters, such as dopamine, are essential biomarkers for diagnosing neurological disorders (Parkinson’s disease, depression, schizophrenia,…
We are pleased to invite you to JCI 2026 Illkirch Campus days on Thursday, May 21, and Friday, May 22, at the Pôle API. JCI 2026 is a…
The Laboratory of Bioimaging and Pathology is immensely proud to announce that Andrey Klymchenko, director of the Photoactive Materials and Bioimaging…
The RISEst and Alsace FBI Node microscopy core facilities are organising a workshops on "Introduction to bio-image processing and analysis with…
New mapping revolutionizes glioblastoma management
We are proud to announce the publication of the work of Nathan Aknine, Rémi Pelletier and Andrey Klymchenko from the Photoactive Materials and…
Klymchenko team, in collaboration with BrightSens Diagnostics and teams of Pfeiffer (UPR9002-CNRS ARN) and Fafi- Kremer (HUS), has developed a…
New probes for imaging lipid droplets Nathan Aknine, a PhD student in the Photoactive Materials and Bioimaging team, recently published a paper with…
UpConverting NanoParticles (UCNPs) are capable of emitting visible light very efficiently after excitation by infrared light. UCNPs’ Anti-Stockes…
Human immunodeficiency virus type 1 (HIV-1) causes AIDS and is a member of envelope viruses in which virus particles are surrounded by a lipid…
Photo-convertible fluorescent probes are able to change their emission color upon light irradiation. This phenomenon is advantageously used in…
Kinetics of protein-assisted nucleic acid interconversion monitored by transient time resolved fluorescence in microfluidic droplets Interconversio…
Intermolecular dark resonance energy transfer (DRET): upgrading fluorogenic DNA sensing FRET sensitivity is usually limited by the spectral…
Fundamental photophysics of isomorphic and expanded fluorescent nucleoside analogues Isomorphic and expanded fluorescent nucleoside analogues are…
Under the title “What makes thienoguanosine an outstanding fluorescent DNA probe?”, the work of the Laboratory of Bioimaging and Pathologies (CNRS /…
With the title in French « Les photons associent leur énergie pour améliorer l’imagerie », collective data from the Institut pluridisciplinaire Hubert…
The group of A. Klymchenko “Nanochemistry and Bioimaging” developed DNA-functionalized fluorescent polymeric nanoparticles for amplified detection of…
