The OnKO•3T team is pleased to announce the publication of a comprehensive review in the journal *Histology and Histopathology*, titled : "CDKN2A alterations in solid tumors: From biological mechanisms to clinical applications, with special emphasis on central nervous system tumors". The CDKN2A…
The physiological role of lipid asymmetry in intracellular membranes remains poorly understood. However, this asymmetry plays a key role in many cellular processes, including membrane trafficking and autophagy. A new publication by Toshihide Kobayashi's group in the BIMC team, led by Yves Mély,…
Avantika Kapoor under the supervision of Halina Anton and Pascal Didier from Andrey Klymchenko’s team, has published her paper, “Fluorescence-Based Microviscosity Mapping in Membraneless Organelles” in the journal ACS Chemical & Biomedical Imaging. The team developed an integrated strategy…
Active targeting of tumor cells relies on the use of ligands capable of specifically binding to receptors that are overexpressed on their surface, such as EGFR (epidermal growth factor receptor). Among these ligands, monoclonal antibodies and aptamers are promising tools for the targeted delivery of…
Nanoparticles (NPs) play a key role in biological applications, such as bioimaging and biosensing. Their stealth properties—that is, their ability to avoid nonspecific interactions with biological environments—is essential to ensuring their stability and efficacy in vivo. Until now, polyethylene…
The team led by Prof. Yves MELY, with Pankhi Singh and Dipanjan Mukherjee as first authors, has just published a major study in the field of structural biology. Their work reveals how thienoguanosine (thG), a fluorescent isomorphic analog of guanosine, enables the exploration of the structure and…
Neurotransmitters, such as dopamine, are essential biomarkers for diagnosing neurological disorders (Parkinson’s disease, depression, schizophrenia, etc.). However, their detection in biological fluids remains challenging due to their low concentration (on the order of nanomolar) and their structura…
Maeva Martin, first author—under the supervision of Laurence Choulier - and co-directed by Julie Helms - along with Marine Tschirhart, Cyril Auger, and Florence Toti from the UMR 1260 Regenerative Nanomedicine unit (University of Strasbourg/Inserm), present a new review published in Annals of…
Rémi Pelletier, Anila Hoskere Ashoka and Andrey Klymchenko, de l'équipe Matériaux photoactifs et bioimagerie, from the Photoactive Materials and Bioimaging team, have developed fluorescent polymer nanofibers that act as multiplexed ratiometric sensors for pH and oxygen, two key parameters in the…
A collaborative work of Tanushree Gupta and Andrey Klymchenko with Michael Ryckelynck, Janine KEHRLI and Roger Cubí Piqué from UPR9002-IBMC, Strasbourg, resulted in oShark, a chemically modified light-up aptamer designed to resist degradation in complex biological environments, which is now…
Photodynamic therapy (PDT) is a promising strategy against head and neck squamous cell carcinoma (HNSCC). In this study led by Chloé Thibaudeau et Alain Jung from the ONKO3T team, in collaboration with Professor Gilles GASSER, they investigated how different ruthenium(II)-based photosensitizers…
We are pleased to announce the publication of a study conducted by Nario TOMISHIGE, Yves MELY, and Toshihide KOBAYASHI on how the HIV-1 Gag protein reorganizes lipids in the host plasma membrane. HIV-1 is enveloped in a membrane derived from the host cell, which is notably enriched in specific…
New publication: Decoding the blinking of fluorescent polymer nanoparticles Interdisciplinary collaboration between chemists and physicists from Andrey Klymchenko's team— Deep Sekhar Biswas, Benjamin Boglio and Pascal Didier — and theorists from the University of Bologna: Giacomo Fanciullo, Silvia…
Read Marion Riegert's popular science article published in the University of Strasbourg's Savoir(s) magazine, which explains the role of UHRF1 in the transmission of epigenetic memory in cells. Link : Le mécanisme de la protéine UHRF1 mis en lumière | Savoirs - Le quotidien de l’Université de…
Lipid nanoemulsions (NEs) are promising eco-friendly nanocarriers for diagnostic and therapeutic applications. However, functionalizing them with biomolecules, such as antibodies, remains difficult due to the liquid nature of their core. In this study, Andrey Klymchenko's team, with Valeria Jose…
The DNA-PAINT (Point Accumulation for Imaging in Nanoscale Topography) technique exploits transient hybridization of DNA strands to achieve nanometric resolution. Although effective, it remains limited in its standard form by background noise generated by unbound strands and slow image acquisition. …
Dipanjan Mukherjee and members of the BIMC team led by Yves Mély, along with their collaborators from the Instituto de Química Física Blas Cabrera (IQF-CSIC), the Université de SanDiego, the Istituto Biostrutture eBioimmagini and the Università Di Siena have just published a new article in the…
We are pleased to announce the publication of a scientific article co-authored by several members of the BIMC team: Ludovic Richert, Patrice Rassam, and Yves Mély in Ebiomedecine: “Directed-complement killing of Pseudomonas aeruginosa protects against lethal pneumonia” Background Pseudomonas…
We are pleased to announce the publication in the scientific journal Nanoscale (Royal Society of Chemistry) of work carried out by Paraskevi Gaki from Andrey Klymchenko's team in collaboration with BrightSens Diagnostics, as part of a Cifre project. The study presents the development of fluorescen…
Olha Tkach and members of the Biophotonics of Molecular and Cellular Interactions team led by Yves Mély, , in collaboration with the Instituto de Química Física Blas Cabrera (IQF-CSIC) de Madrid, the Consiglio Nazionale delle Ricerche - Istituto Biostrutture e Bioimmagini, the Department of…
