Lipid nanoemulsions (NEs) are promising eco-friendly nanocarriers for diagnostic and therapeutic applications. However, functionalizing them with biomolecules, such as antibodies, remains difficult due to the liquid nature of their core.
In this study, Andrey Klymchenko's team, with Valeria Jose BOIDE-TRUJILLO as the first author and in collaboration with with Jacky Goetz’s team of Tumor Biomechanics (INSERM UMR_S1109) and Nicolas Anton from the Regenerative Nanomedicine Laboratory (INSERM UMR_1260), developed a new “plug-and-play” methodology that enables antibodies to be efficiently grafted onto the surface of NEs based on components recognized as safe (GRAS).
They demonstrated:
- the synthesis and characterization of an amphiphilic biotin-PEG3000-cholesterol ligand;
- the controlled biotinylation of lipid NEs;
- the specific targeting of trastuzumab antibodies to HER2+ breast cancer cells.
These results pave the way for new biomedical applications of lipid NEs, combining durability and therapeutic performance.
Congratulations to the entire team and their collaborators!
Link : Functionalization of lipid nanoemulsions with humanized antibodies using plug-and-play cholesterol anchor for targeting cancer cells https://doi.org/10.1039/D5NA00606F
