Publications

Fuchs Q, Batut A, Gleyzes M, Rontard J, Miny L, Libralato M, Vieira J, Debis D, Larramendy F, Honegger T, Messe M, Pierrevelcin M, Lhermitte B, Dontenwill M, Entz-Werlé N. (2021). Co-culture of glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions. J Vis Exp. 177. doi: 10.3791/62748

Burgy M, Jehl A, Conrad O, Foppolo S, Bruban V, Etienne-Selloum N, Jung AC, Masson M, Macabre C, Ledrappier S, Burckel H, Mura C, Noël G, Borel C, Fasquelle F, Onea MA, Chenard MP, Thiéry A, Dontenwill M, Martin S. (2021). Cav1/EREG/YAP axis in the treatment resistance of Cav1-expressing head and neck squamous cell carcinoma. Cancers (Basel). 13(12):3038. doi: 10.3390/cancers13123038

Etienne-Selloum, N., Prades, J., Bello Roufai, D., Boone, M., Sevestre, H., Trudel, S., Caillet, P., Coutte, A.,Desenclos, C., Constans, JM., Martin, S., Choulier, L., Chauffert, B. & Dontenwill, M. Expression analysis of α5 integrin subunit reveals its upregulation as a negative prognostic biomarker for glioblastoma. Pharmaceuticals 14(9):882. doi: 10.3390/ph14090882

Blandin, A.-F., Cruz Da Silva, E., Mercier, M.-C., Glushonkov, O., Didier, P., Dedieu, S., Schneider, C., Devy, J., Etienne-Selloum, N., Dontenwill, M., Choulier, L. & Lehmann, M. (2020). Gefitinib induces EGFR and α5β1 integrin co-endocytosis in glioblastoma cells. Cell Mol Life Sci. 78(6):2949-2962. DOI: 10.1007/s00018-020-03686-6 

Colin, F., Schauer, K., Hamiche, A., Martineau, P., Borg, J.-P., Bednar, J., Bertolin, G., Camoin, L., Collette, Y., Dimitrov, S., Fournier, I., Hyenne, V., Mendoza-Parra, M.A., Morelli, X., Rondé, P., Sumara, I., Tramier, M., Schultz, P. & Goetz, J. (2021). The NANOTUMOR consortium - towards the Tumor Cell Atlas. Biol Cell. DOI: 10.1111/boc.202000135 

Cruz Da Silva, E., Mercier, M-C., Etienne-Selloum, N., Dontenwill, M. & Choulier, L. (2021). A systematic review of glioblastoma targeted therapies in Phases II, III, IV clinical trials. Cancers. 13(8), 1795. DOI: 10.3390/cancers13081795

Egloff, S., Melnychuk, N., Reisch, A., Martin, S., Klymchenko, A.S. (2021). Enzyme-free amplified detection of cellular microRNA by light-harvesting fluorescent nanoparticle probes. Biosensors and Bioelectronics 179, 113084. DOI: 10.1016/j.bios.2021.113084 

Gomez-Brouchet, A., Gilhodes, J., Acker, N.V., Brion, R., Bouvier, C., Assemat, P., Gaspar, N., Aubert, S., Guinebretiere, J.-M., Marie, B., Larousserie, F., Entz-Werlé, N., Pinieux, G., Mascard, E., Gouin, F., Brousset, P., Tabone, M.D., Jimenez, M., Le Deley, M.C., Blay, J.Y., Brugieres, L., Piperno-Neumann, S. & Rédini, F. (2021). Characterization of Macrophages and Osteoclasts in the Osteosarcoma Tumor Microenvironment at Diagnosis: New Perspective for Osteosarcoma Treatment? Cancers (Basel) 13(3), 423. DOI: 10.3390/cancers13030423

Sani, S., Messe, M., Fuchs, Q., Pierrevelcin, M., Laquerriere, P., Entz-Werle, N., Reita, D., Etienne-Selloum, N., Bruban, V., Choulier, L., Martin, S. & Dontenwill, M. (2021). Biological Relevance of RGD-Integrin Subtype-Specific Ligands in Cancer. Chembiochem. 22(7):1151-1160. DOI: 10.1002/cbic.202000626 

Schraub, S., Blaise, P., Noel, G., Casset, A., Etienne-Selloum, N., Da Silva, F., Marchal, P., Schneider, G., Bergerot, P. (2021) Patients acteurs et formation en oncologie pour futurs médecins et pharmaciens [Impact of patient testimony in the education of medicine and pharmacy students]. Bull Cancer. 2021, 108(1):23-29. DOI: 10.1016/j.bulcan.2020.10.023 

Barkaoui, M.-A., Queheille, E., Aladjidi, N., Plat, G., Jeziorski, E., Moshous, D., Lambilliotte, A., Kebaili, K., Pacquement, H., Leverger, G., Mansuy, L., Entz-Werlé, N., Bodet, D., Schneider, P., Pagnier, A., Lutun, A., Gillibert-Yvert, M., Millot, F., Toutain, F., Reguerre, Y., Thomas, C., Tazi, A., Emile, J.F., Donadieu, J. & Héritier, S.. (2020). Long-term follow-up of children with risk organ-negative Langerhans cell histiocytosis after 2-chlorodeoxyadenosine treatment. Br J Haematol. 191(5):825-834. DOI: 10.1111/bjh.16944 

Benesch, M., Nemes, K., Neumayer, P., Hasselblatt, M., Timmermann, B., Bison, B., Ebetsberger-Dachs, G., Bourdeaut, F., Dufour, C., Biassoni, V., Morales La Madrid, A., Entz-Werlé, N., Laithier, V., Quehenberger, F., Weis, S., Sumerauer, D., Siebert, R., Bens, S., Schneppenheim, R., Kool, M., Modena, P., Fouyssac, F. & Frühwald, M.C. (2020). Spinal cord atypical teratoid/rhabdoid tumors in children: Clinical, genetic, and outcome characteristics in a representative European cohort. Pediatr Blood Cancer 67, e28022. DOI: 10.1002/pbc.28022  

Clément, C.M.H., Deffieu, M.S., Dorobantu, C.M., Baumert, T.F., Ayala-Nunez, N.V., Mély, Y., Ronde, P., and Gaudin, R. (2020). Characterisation of endogenous Claudin-1 expression, motility and susceptibility to hepatitis C virus in CRISPR knock-in cells. Biol Cell 112(5), 140–151. DOI: 10.1111/boc.201900085

Dufour, C., Foulon, S., Geoffray, A., Masliah-Planchon, J., Figarella-Branger, D., Guerrini-Rousseau, L., Faure-Conter, C., Icher, C., Bertozzi, A.-I., Leblond, P., Akbaraly, T., Bourdeaut, F., André, N., Chappé, C., Schneider, P., De Carli, E., Chastagner, P., Berger, C., Lejeune, J., Soler, C., Entz-Werlé, N. & Delisle, M.B. (2020). Prognostic relevance of clinical and molecular risk factors in children with high-risk medulloblastoma treated in the phase 2 trial PNET HR+5. Neuro Oncol. noaa301. DOI: 10.1093/neuonc/noaa301

Eve, L., Fervers, B., Le Romancer, M., and Etienne-Selloum, N. (2020). Exposure to Endocrine Disrupting Chemicals and Risk of Breast Cancer. Int J Mol Sci 21.(23):9139. DOI: 10.3390/ijms21239139

Fructuoso, M., Legrand, M., Mousson, A., Steffan, T., Vauchelles, R., De Mey, J., Sick, E., Rondé, P., and Dujardin, D. (2020). FAK regulates dynein localisation and cell polarity in migrating mouse fibroblasts. Biol Cell 112(2), 53–72. DOI: 10.1111/boc.201900041

Fuchs, Q., Pierrevelcin, M., Messe, M., Lhermitte, B., Blandin, A.-F., Papin, C., Coca, A., Dontenwill, M., and Entz-Werlé, N. (2020). Hypoxia Inducible Factors’ Signaling in Pediatric High-Grade Gliomas: Role, Modelization and Innovative Targeted Approaches. Cancers (Basel) 12(4):979. DOI: 10.3390/cancers12040979

Gries, M., Thomas, N., Daouk, J., Rocchi, P., Choulier, L., Jubréaux, J., Pierson, J., Reinhard, A., Jouan-Hureaux, V., Chateau, A., Acherar, S., Frochot, C., Lux, F., Tillement, O. & Barberi-Heyob, M. (2020). Multiscale Selectivity and in vivo Biodistribution of NRP-1-Targeted Theranostic AGuIX Nanoparticles for PDT of Glioblastoma. Int J Nanomedicine 15, 8739–8758. DOI: 10.2147/IJN.S261352

Harmouch, E., Seitlinger, J., Chaddad, H., Ubeaud-Sequier, G., Barths, J., Saidu, S., Désaubry, L., Grandemange, S., Massfelder, T., Fuhrmann, G., Fioretti, F., Dontenwill, M., Benkirane-Jessel, N. & Idoux-Gillet, Y. (2020). Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes. Sci Rep 10(1), 13750. DOI: 10.1038/s41598-020-70820-6

Pierrevelcin, M., Fuchs, Q., Lhermitte, B., Messé, M., Guérin, E., Weingertner, N., Martin, S., Lelong-Rebel, I., Nazon, C., Dontenwill, M. & Entz-werlé, N. (2020). Focus on Hypoxia-Related Pathways in Pediatric Osteosarcomas and Their Druggability. Cells 9.(9):1998. DOI: 10.3390/cells9091998

Runser, A., Dujardin, D., Ernst, P., Klymchenko, A.S., and Reisch, A. (2020). Zwitterionic Stealth Dye-Loaded Polymer Nanoparticles for Intracellular Imaging. ACS Appl Mater Interfaces 12(1), 117–125. DOI: 10.1021/acsami.9b15396 

Todeschi, J., Stella, I., Entz-Werle, N., Coca, H.A., Joud, A., Chastagner, P., Proust, F., and Klein, O. (2020). Cerebellar swelling after surgery for medulloblastoma with leptomeningeal dissemination in children. A case based-update. Neurochirurgie 67(2):145-151. DOI: 10.1016/j.neuchi.2020.11.015  

Vautrin-Glabik, A., Devy, J., Bour, C., Baud, S., Choulier, L., Hoarau, A., Dupont-Deshorgue, A., Sellier, C., Brassart, B., Oudart, J.-B., Ramont, L., Monboisse, J.C. & Brassart-Pasco, S. (2020). Angiogenesis Inhibition by a Short 13 Amino Acid Peptide Sequence of Tetrastatin, the α4(IV) NC1 Domain of Collagen IV. Front Cell Dev Biol 8, 775. DOI: 10.3389/fcell.2020.00775

Blandin, A.-F., Durand, A., Litzler, M., Tripp, A., Guérin, É., Ruhland, E., Obrecht, A., Keime, C., Fuchs, Q., Reita, D., Lhermitte, B., Coca, A., Jones, C., Lelong Rebel, I., Villa, P., Namer, I.J., Dontenwill, M., Guenot, D. & Entz-Werlé, N.. (2019). Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity. Cancers (Basel) 11.(12):1875. DOI: 10.3390/cancers11121875

Collot, M., E. Boutant, M. Lehmann, and A. S. Klymchenko. (2019). BODIPY with Tuned Amphiphilicity as a Fluorogenic Plasma Membrane Probe. Bioconjugate Chemistry, 30(1) , 192–199. DOI: 10.1021/acs.bioconjchem.8b00828

Cruz da Silva, E., Dontenwill, M., Choulier, L., and Lehmann, M. (2019). Role of Integrins in Resistance to Therapies Targeting Growth Factor Receptors in Cancer. Cancers (Basel) 11(5):692. DOI: 10.3390/cancers11050692

Fechter, P., Cruz Da Silva, E., Mercier, M.-C., Noulet, F., Etienne-Seloum, N., Guenot, D., Lehmann, M., Vauchelles, R., Martin, S., Lelong-Rebel, I., Ray, A.M., Seguin, C., Dontenwill, M. & Choulier, L. (2019). RNA Aptamers Targeting Integrin α5β1 as Probes for Cyto- and Histofluorescence in Glioblastoma. Mol Ther Nucleic Acids 17, 63–77. DOI: 10.1016/j.omtn.2019.05.006

Groysbeck, N., Stoessel, A., Donzeau, M., da Silva, E.C., Lehmann, M., Strub, J.-M., Cianferani, S., Dembélé, K., and Zuber, G. (2019). Synthesis and biological evaluation of 2.4 nm thiolate-protected gold nanoparticles conjugated to Cetuximab for targeting glioblastoma cancer cells via the EGFR. Nanotechnology 30(18), 184005. DOI: 10.1088/1361-6528/aaff0a 

Job, S., Reyniès, A. de, Heller, B., Weiss, A., Guérin, E., Macabre, C., Ledrappier, S., Bour, C., Wasylyk, C., Etienne-Selloum, N., Brino, L., Gaiddon, C., Wasylyk, B. & Jung, A. (2019). Preferential Response of Basal-Like Head and Neck Squamous Cell Carcinoma Cell Lines to EGFR-Targeted Therapy Depending on EREG-Driven Oncogenic Addiction. Cancers (Basel) 11.(6):795. DOI: 10.3390/cancers11060795

Morisse, M.C., Etienne-Selloum, N., Bello-Roufai, D., Blonski, M., Taillandier, L., Lorgis, V., Noël, G., Ahle, G., Durán-Peña, A., Boone, M. & Chauffert, B. (2019). Long-term survival in patients with recurrent glioblastoma treated with bevacizumab: a multicentric retrospective study. J Neurooncol 144(2), 419–426. DOI: 10.1007/s11060-019-03245-5 

Reita, D., Bour, C., Benbrika, R., Groh, A., Pencreach, E., Guérin, E., and Guenot, D. (2019). Synergistic Anti-Tumor Effect of mTOR Inhibitors with Irinotecan on Colon Cancer Cells. Cancers (Basel) 11(10):1581. DOI: 10.3390/cancers11101581

Alamgeer, Auger, C., Chabert, P., Lugnier, C., Mushtaq, M.N., and Schini-Kerth, V.B. (2018). Mechanisms underlying vasorelaxation induced in the porcine coronary arteries by Thymus linearis, Benth. J Ethnopharmacol 225, 211–219. DOI: 10.1016/j.jep.2018.07.010

Boyrie, S., Delmas, C., Lemarié, A., Lubrano, V., Dahan, P., Malric, L., Luis, J., Gilhodes, J., Tosolini, M., Mouly, L., Lehmann, M., Toulas, C., Cohen-Jonathan Moyal, E. & Monferran, S. (2018). RND1 regulates migration of human glioblastoma stem-like cells according to their anatomical localization and defines a prognostic signature in glioblastoma. Oncotarget 9, 33788–33803. DOI: 10.18632/oncotarget.26082

Gaspar, N., Occean, B.-V., Pacquement, H., Bompas, E., Bouvier, C., Brisse, H.J., Castex, M.-P., Cheurfa, N., Corradini, N., Delaye, J., Entz-Werlé et al. (2018). Results of methotrexate-etoposide-ifosfamide based regimen (M-EI) in osteosarcoma patients included in the French OS2006/sarcome-09 study. Eur J Cancer 88, 57–66. DOI: 10.1016/j.ejca.2017.09.036

Kuonen, F., Surbeck, I., Sarin, K.Y., Dontenwill, M., Rüegg, C., Gilliet, M., Oro, A.E., and Gaide, O. (2018). TGFβ, Fibronectin and Integrin α5β1 Promote Invasion in Basal Cell Carcinoma. J Invest Dermatol 138, 2432–2442. DOI: 10.1016/j.jid.2018.04.029

Lhermitte, B., Blandin, A.F., Coca, A., Guerin, E., Durand, A., and Entz-Werlé, N. (2018). Signaling pathway deregulation and molecular alterations across pediatric medulloblastomas. Neurochirurgie. 67(1):39-45. DOI: 10.1016/j.neuchi.2018.01.003 

Lui, G., Bouazza, N., Denoyelle, F., Moine, M., Brugières, L., Chastagner, P., Corradini, N., Entz-Werle, N., Vérité, C., Landmanparker, J., et al. (2018a). Association between genetic polymorphisms and platinum-induced ototoxicity in children. Oncotarget 9(56), 30883–30893. DOI: 10.18632/oncotarget.25767 

Lui, G., Treluyer, J.-M., Fresneau, B., Piperno-Neumann, S., Gaspar, N., Corradini, N., Gentet, J.-C., Marec Berard, P., Laurence, V., Schneider, P., et al. (2018b). A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial. J Clin Pharmacol 58(12), 1541–1549. DOI: 10.1002/jcph.1252 

Mousson, A., Sick, E., Carl, P., Dujardin, D., De Mey, J., and Rondé, P. (2018). Targeting Focal Adhesion Kinase Using Inhibitors of Protein-Protein Interactions. Cancers (Basel) 10.

Reisch, A.,, Heimburger, D., Ernst, P., Runser, A., Didier, P., Dujardin, D., and Klymchenko, A.S. (2018). Protein-sized dye-loaded polymer nanoparticles for free particle diffusion in cytosol. Adv. Funct. Mater. 28, 1805157.

Verschuur, A., Heng-Maillard, M.-A., Dory-Lautrec, P., Truillet, R., Jouve, E., Chastagner, P., Leblond, P., Aerts, I., Honoré, S., Entz-Werle, N., et al. (2018). Metronomic Four-Drug Regimen Has Anti-tumor Activity in Pediatric Low-Grade Glioma; The Results of a Phase II Clinical Trial. Front Pharmacol 9, 00950. DOI: 10.3389/fphar.2018.00950

Vinci, M., Burford, A., Molinari, V., Kessler, K., Popov, S., Clarke, M., Taylor, K.R., Pemberton, H.N., Lord, C.J., Gutteridge, A., et al. (2018). Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells. Nat Med 24(8), 1204–1215. DOI: 10.1038/s41591-018-0086-7

Mercier, M.-C., Dontenwill, M., and Choulier, L. (2017). Selection of Nucleic Acid Aptamers Targeting Tumor Cell-Surface Protein Biomarkers. Cancers (Basel) 9(6):69. DOI: 10.3390/cancers9060069

Akasov, R., Zaytseva-Zotova, D., Burov, S., Leko, M., Dontenwill, M., Chiper, M., Vandamme, T., and Markvicheva, E. (2016). Formation of multicellular tumor spheroids induced by cyclic RGD-peptides and use for anticancer drug testing in vitro. Int J Pharm 506, 148–157.

Alamgeer, null, Chabert, P., Akhtar, M.S., Jabeen, Q., Delecolle, J., Heintz, D., Garo, E., Hamburger, M., Auger, C., Lugnier, C., et al. (2016). Endothelium-independent vasorelaxant effect of a Berberis orthobotrys root extract via inhibition of phosphodiesterases in the porcine coronary artery. Phytomedicine 23, 793–799.

Blandin, A.-F., Noulet, F., Renner, G., Mercier, M.-C., Choulier, L., Vauchelles, R., Ronde, P., Carreiras, F., Etienne-Selloum, N., Vereb, G., et al. (2016). Glioma cell dispersion is driven by α5 integrin-mediated cell–matrix and cell–cell interactions. Cancer Letters 376, 328–338.

Karicheva, O., Rodriguez-Vargas, J.M., Wadier, N., Martin-Hernandez, K., Vauchelles, R., Magroun, N., Tissier, A., Schreiber, V., and Dantzer, F. (2016). PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis. Oncotarget 7, 64109–64123.

Khiralla, A., Mohamed, I.E., Tzanova, T., Schohn, H., Slezack-Deschaumes, S., Hehn, A., André, P., Carre, G., Spina, R., Lobstein, A., et al. (2016). Endophytic fungi associated with Sudanese medicinal plants show cytotoxic and antibiotic potential. FEMS Microbiol Lett 363.

Krifa, M., El Meshri, S.E., Bentouati, N., Pizzi, A., Sick, E., Chekir-Ghedira, L., and Rondé, P. (2016). In Vitro and In Vivo Anti-Melanoma Effects of Pituranthos tortuosus Essential Oil Via Inhibition of FAK and Src Activities. J Cell Biochem 117, 1167–1175.

Renner, G., Janouskova, H., Noulet, F., Koenig, V., Guerin, E., Bär, S., Nuesch, J., Rechenmacher, F., Neubauer, S., Kessler, H., et al. (2016a). Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma. Cell Death Differ. 23, 640–653.

Renner, G., Noulet, F., Mercier, M.-C., Choulier, L., Etienne-Selloum, N., Gies, J.-P., Lehmann, M., Lelong-Rebel, I., Martin, S., and Dontenwill, M. (2016b). Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells. Oncotarget 7, 62194–62207.

Vivot, K., Benahmed, M.A., Seyfritz, E., Bietiger, W., Elbayed, K., Ruhland, E., Langlois, A., Maillard, E., Pinget, M., Jeandidier, N., Gies, J.P., Namer, I.J., Sigrist, S., and Reix, N. (2016). A metabolomic approach (1H HRMAS NMR spectroscopy) supported by histology to study early post-transplantation responses in islet-transplanted livers. Int. J. Biol. Sci. 12, 1168-1180.

Abusnina, A., Keravis, T., Zhou, Q., Justiniano, H., Lobstein, A., and Lugnier, C. (2015). Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition. Thromb Haemost 113, 319–328.

Anton, H., Taha, N., Boutant, E., Richert, L., Khatter, H., Klaholz, B., Rondé, P., Réal, E., de Rocquigny, H., and Mély, Y. (2015). Investigating the cellular distribution and interactions of HIV-1 nucleocapsid protein by quantitative fluorescence microscopy. PLoS One 10, e0116921.

Ayme-Dietrich, E., Marzak, H., Lawson, R., Mokni, W., Wendling, O., Combe, R., Becker, J., El Fertak, L., Champy, M.-F., Matz, R., et al. (2015). Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats. J Hypertens 33, 2310–2321.

Blandin, A.-F., Renner, G., Lehmann, M., Lelong-Rebel, I., Martin, S., and Dontenwill, M. (2015). β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer. Front Pharmacol 6, 279.

Boukhari, A., Alhosin, M., Bronner, C., Sagini, K., Truchot, C., Sick, E., Schini-Kerth, V.B., André, P., Mély, Y., Mousli, M., et al. (2015). CD47 activation-induced UHRF1 over-expression is associated with silencing of tumor suppressor gene p16INK4A in glioblastoma cells. Anticancer Res 35, 149–157.

Carré, G., , Garnier, L., Moeller-Siegert, J., Gies, J.P., Keller, V., André, P., and Keller, N. (2015). Antibacterial textiles functionalized by layer-by-layer assembly of polyelectrolytes and TiO2 photocatalyst. RSC Adv. 5, 38859-38867.

Clauss, F., Charloux, A., Piquard, F., Doutreleau, S., Talha, S., Zoll, J., Lugnier, C., and Geny, B. (2015). Angiotensin-converting enzyme inhibition prevents myocardial infarction-induced increase in renal cortical cGMP and cAMP phosphodiesterase activities. Fundam Clin Pharmacol 29, 352–361.

El Meshri, S.E., Dujardin, D., Godet, J., Richert, L., Boudier, C., Darlix, J.L., Didier, P., Mély, Y., and de Rocquigny, H. (2015). Role of the nucleocapsid domain in HIV-1 Gag oligomerization and trafficking to the plasma membrane: a fluorescence lifetime imaging microscopy investigation. J Mol Biol 427, 1480–1494.

Jeanne, A., Sick, E., Devy, J., Floquet, N., Belloy, N., Theret, L., Boulagnon-Rombi, C., Diebold, M.-D., Dauchez, M., Martiny, L., et al. (2015). Identification of TAX2 peptide as a new unpredicted anti-cancer agent. Oncotarget 6, 17981–18000.

Jung, A.C., Ray, A.-M., Ramolu, L., Macabre, C., Simon, F., Noulet, F., Blandin, A.-F., Renner, G., Lehmann, M., Choulier, L., et al. (2015). Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties. Oncotarget 6, 41884–41901.

Keravis, T., Favot, L., Abusnina, A.A., Anton, A., Justiniano, H., Soleti, R., Alabed Alibrahim, E., Simard, G., Andriantsitohaina, R., and Lugnier, C. (2015). Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells. PLoS One 10, e0145291.

Leon-Gonzalez*, AJ., Sharif*, T., Kayali A., Abbas, M., Dandache, I.,  Etienne-selloum, N., Kevers, C., Pincemail, J., Auger, C., Chabert, P., Alhosin, M., and Schini-Kerth, V.B. (2015). Delphinidin-3-O-glucoside and delphinidin-3-O-rutinoside mediate the redox-sensitive caspase 3-related pro-apoptotic effect of blackcurrant juice on leukaemia Jurkat cells (*co-first authors). J. Funct. Food. 17, 847-856, 2015

Mlih, M., Host, L., Martin, S., Niederhoffer, N., Monassier, L., Terrand, J., Messaddeq, N., Radke, M., Gotthardt, M., Bruban, V., et al. (2015). The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development. J Biol Chem 290, 2419–2430.

Nominé, Y., Choulier, L., Travé, G., Vernet, T., and Altschuh, D. (2015). Antibody Binding Selectivity: Alternative Sets of Antigen Residues Entail High-Affinity Recognition. PLoS One 10, e0143374.

Sholokh, M., Zamotaiev, O.M., Das, R., Postupalenko, V.Y., Richert, L., Dujardin, D., Zaporozhets, O.A., Pivovarenko, V.G., Klymchenko, A.S., and Mély, Y. (2015). Fluorescent amino acid undergoing excited state intramolecular proton transfer for site-specific probing and imaging of peptide interactions. J Phys Chem B 119, 2585–2595.

Vernet, T., Choulier, L., Nominé, Y., Bellard, L., Baltzinger, M., Travé, G., and Altschuh, D. (2015). Spot peptide arrays and SPR measurements: throughput and quantification in antibody selectivity studies. J Mol Recognit 28, 635–644.

Beck, C., Boehler, C., Guirouilh Barbat, J., Bonnet, M.-E., Illuzzi, G., Ronde, P., Gauthier, L.R., Magroun, N., Rajendran, A., Lopez, B.S., et al. (2014). PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways. Nucleic Acids Res 42, 5616–5632.

Carré, G., Hamon, E., Ennahar, S., Estner, M., Lett, M.-C., Horvatovich, P., Gies, J.-P., Keller, V., Keller, N., and Andre, P. (2014). TiO2 photocatalysis damages lipids and proteins in Escherichia coli. Appl Environ Microbiol 80, 2573–2581.

Darwich, Z., Klymchenko, A.S., Dujardin, D., and Mély, Y. (2014). Imaging lipid order changes in endosome membranes of live cells by using a Nile Red-based membrane probe. RSC Adv. 4, 8481-8488, 2014

Deramaudt, T.B., Dujardin, D., Noulet, F., Martin, S., Vauchelles, R., Takeda, K., and Rondé, P. (2014). Altering FAK-paxillin interactions reduces adhesion, migration and invasion processes. PLoS One 9, e92059.

Hamadi, A., Giannone, G., Takeda, K., and Rondé, P. (2014). Glutamate involvement in calcium-dependent migration of astrocytoma cells. Cancer Cell Int 14, 42.

Kolli-Bouhafs, K., Sick, E., Noulet, F., Gies, J.-P., De Mey, J., and Rondé, P. (2014). FAK competes for Src to promote migration against invasion in melanoma cells. Cell Death Dis 5, e1379.

Pinel, S., Aman, E., Erblang, F., Dietrich, J., Frisch, B., Sirman, J., Kichler, A., Sibler, A.-P., Dontenwill, M., Schaffner, F., et al. (2014). Quantitative measurement of delivery and gene silencing activities of siRNA polyplexes containing pyridylthiourea-grafted polyethylenimines. J Control Release 182, 1–12.

Ray, A.-M., Schaffner, F., Janouskova, H., Noulet, F., Rognan, D., Lelong-Rebel, I., Choulier, L., Blandin, A.-F., Lehmann, M., Martin, S., et al. (2014). Single cell tracking assay reveals an opposite effect of selective small non-peptidic α5β1 or αvβ3/β5 integrin antagonists in U87MG glioma cells. Biochim. Biophys. Acta 1840, 2978–2987.

Schlur, L., Begin-Colin, S., Gilliot, P., Gallart, M., Carré, G., Zafeiratos, S., Keller, N., Keller, V., André, P., Greneche, J.-M., et al. (2014). Effect of ball-milling and Fe-/Al-doping on the structural aspect and visible light photocatalytic activity of TiO2 towards Escherichia coli bacteria abatement. Mater Sci Eng C Mater Biol Appl 38, 11–19.

Tam, J.C.-W., Ko, C.-H., Lau, K.-M., To, M.-H., Kwok, H.-F., Chan, Y.-W., Siu, W.-S., Etienne-Selloum, N., Lau, C.-P., Chan, W.-Y., et al. (2014). A Chinese 2-herb formula (NF3) promotes hindlimb ischemia-induced neovascularization and wound healing of diabetic rats. J Diabetes Complications 28, 436–447.

Vivot, K., Langlois, A., Bietiger, W., Dal, S., Seyfritz, E., Pinget, M., Jeandidier, N., Maillard, E., Gies, J.-P., and Sigrist, S. (2014). Pro-inflammatory and pro-oxidant status of pancreatic islet in vitro is controlled by TLR-4 and HO-1 pathways. PLoS One 9, e107656.

Yougbaré, I., Keravis, T., Abusnina, A., Decossas, M., Schall, N., Muller, S., and Lugnier, C. (2014). Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling. Biochim Biophys Acta 1842, 916–926.

Akcora, D., Huynh, D., Lightowler, S., Germann, M., Robine, S., de May, J.R., Pollard, J.W., Stanley, E.R., Malaterre, J., and Ramsay, R.G. (2013). The CSF-1 receptor fashions the intestinal stem cell niche. Stem Cell Res 10, 203–212.

Carré, G., Benhamida, D., Peluso, J., Muller, C.D., Lett, M.-C., Gies, J.-P., Keller, V., Keller, N., and André, P. (2013). On the use of capillary cytometry for assessing the bactericidal effect of TiO2. Identification and involvement of reactive oxygen species. Photochem Photobiol Sci 12, 610–620.

Choulier, L., Nominé, Y., Zeder-Lutz, G., Charbonnier, S., Didier, B., Jung, M.-L., and Altschuh, D. (2013). Chemical library screening using a SPR-based inhibition in solution assay: simulations and experimental validation. Anal. Chem. 85, 8787–8795.

De Mey, J.R., and Freund, J.-N. (2013). Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies. Tissue Barriers 1, e24965.

Duval, M., Korepanov, A., Fuchsbauer, O., Fechter, P., Haller, A., Fabbretti, A., Choulier, L., Micura, R., Klaholz, B.P., Romby, P., et al. (2013). Escherichia coli ribosomal protein S1 unfolds structured mRNAs onto the ribosome for active translation initiation. PLoS Biol 11, e1001731.

Janouskova, H., Ray, A.-M., Noulet, F., Lelong-Rebel, I., Choulier, L., Schaffner, F., Lehmann, M., Martin, S., Teisinger, J., and Dontenwill, M. (2013). Activation of p53 pathway by Nutlin-3a inhibits the expression of the therapeutic target α5 integrin in colon cancer cells. Cancer Lett. 336, 307–318.

Krifa, M., Alhosin, M., Muller, C.D., Gies, J.-P., Chekir-Ghedira, L., Ghedira, K., Mély, Y., Bronner, C., and Mousli, M. (2013). Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation. J Exp Clin Cancer Res 32, 30.

Rabineau, M., Kocgozlu, L., Dujardin, D., Senger, B., Haikel, Y., Voegel, J.-C., Freund, J.-N., Schaaf, P., Lavalle, P., and Vautier, D. (2013). Contribution of soft substrates to malignancy and tumor suppression during colon cancer cell division. PLoS One 8, e78468.

Schaffner, F., Ray, A.M., and Dontenwill, M. (2013a). Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors. Cancers (Basel) 5, 27–47.

Schaffner, F., Yokota, N., Carneiro-Lobo, T., Kitano, M., Schaffer, M., Anderson, G.M., Mueller, B.M., Esmon, C.T., and Ruf, W. (2013b). Endothelial protein C receptor function in murine and human breast cancer development. PLoS One 8, e61071.

Yougbaré, I., Boire, G., Roy, M., Lugnier, C., and Rouseau, E. (2013). NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production. Can J Physiol Pharmacol 91, 353–361.

Alhosin, M., Ibrahim, A., Boukhari, A., Sharif, T., Gies, J.-P., Auger, C., and Schini-Kerth, V.B. (2012). Anti-neoplastic agent thymoquinone induces degradation of α and β tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts. Invest New Drugs 30, 1813–1819.

Altschuh, D., Björkelund, H., Strandgård, J., Choulier, L., Malmqvist, M., and Andersson, K. (2012). Deciphering complex protein interaction kinetics using Interaction Map. Biochem Biophys Res Commun 428, 74–79.

Bellis, J., Duluc, I., Romagnolo, B., Perret, C., Faux, M.C., Dujardin, D., Formstone, C., Lightowler, S., Ramsay, R.G., Freund, J.-N., et al. (2012). The tumor suppressor Apc controls planar cell polarities central to gut homeostasis. J Cell Biol 198, 331–341.

Brants, J., Semenchenko, K., Wasylyk, C., Robert, A., Carles, A., Zambrano, A., Pradeau-Aubreton, K., Birck, C., Schalken, J.A., Poch, O., et al. (2012). Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis. PLoS One 7, e51258.

Cosset, E.C., Godet, J., Entz-Werlé, N., Guérin, E., Guenot, D., Froelich, S., Bonnet, D., Pinel, S., Plenat, F., Chastagner, P., et al. (2012). Involvement of the TGFβ pathway in the regulation of α5 β1 integrins by caveolin-1 in human glioblastoma. Int. J. Cancer 131, 601–611.

Creusat, G., Thomann, J.-S., Maglott, A., Pons, B., Dontenwill, M., Guérin, E., Frisch, B., and Zuber, G. (2012). Pyridylthiourea-grafted polyethylenimine offers an effective assistance to siRNA-mediated gene silencing in vitro and in vivo. J Control Release 157, 418–426.

Faure, E., Garrouste, F., Parat, F., Monferran, S., Leloup, L., Pommier, G., Kovacic, H., and Lehmann, M. (2012). P2Y2 receptor inhibits EGF-induced MAPK pathway to stabilise keratinocyte hemidesmosomes. J Cell Sci 125, 4264–4277.

Janouskova, H., Maglott, A., Leger, D.Y., Bossert, C., Noulet, F., Guerin, E., Guenot, D., Pinel, S., Chastagner, P., Plenat, F., et al. (2012). Integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma. Cancer Res. 72, 3463–3470.

Keravis, T., and Lugnier, C. (2012). Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments. Br J Pharmacol 165, 1288–1305.

Keravis, T., Monneaux, F., Yougbaré, I., Gazi, L., Bourguignon, J.-J., Muller, S., and Lugnier, C. (2012). Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor. PLoS One 7, e28899.

Kolli-Bouhafs, K., Boukhari, A., Abusnina, A., Velot, E., Gies, J.-P., Lugnier, C., and Rondé, P. (2012). Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation. Invest New Drugs 30, 2121–2131.

Kümmerle, A.E., Schmitt, M., Cardozo, S.V.S., Lugnier, C., Villa, P., Lopes, A.B., Romeiro, N.C., Justiniano, H., Martins, M.A., Fraga, C.A.M., et al. (2012). Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors. J Med Chem 55, 7525–7545.

Martin, S., Janouskova, H., and Dontenwill, M. (2012). Integrins and p53 pathways in glioblastoma resistance to temozolomide. Front Oncol 2, 157.

Perrot, G., Langlois, B., Devy, J., Jeanne, A., Verzeaux, L., Almagro, S., Sartelet, H., Hachet, C., Schneider, C., Sick, E., et al. (2012). LRP-1--CD44, a new cell surface complex regulating tumor cell adhesion. Mol Cell Biol 32, 3293–3307.

Schann, S., Greney, H., Gasparik, V., Dontenwill, M., Rascente, C., Lacroix, G., Monassier, L., Bruban, V., Feldman, J., Ehrhardt, J.-D., et al. (2012). Methylation of imidazoline related compounds leads to loss of α₂-adrenoceptor affinity. Synthesis and biological evaluation of selective I₁ imidazoline receptor ligands. Bioorg Med Chem 20, 4710–4715.

Sick, E., Jeanne, A., Schneider, C., Dedieu, S., Takeda, K., and Martiny, L. (2012). CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interest. Br J Pharmacol 167, 1415–1430.

Zeder-Lutz, G., Choulier, L., Besse, M., Cousido-Siah, A., Ruiz Figueras, F.X., Didier, B., Jung, M.-L., Podjarny, A., and Altschuh, D. (2012). Validation of surface plasmon resonance screening of a diverse chemical library for the discovery of protein tyrosine phosphatase 1b binders. Anal Biochem 421, 417–427.

Abusnina, A., Alhosin, M., Keravis, T., Muller, C.D., Fuhrmann, G., Bronner, C., and Lugnier, C. (2011a). Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis. Cell Signal 23, 152–160.

Abusnina, A., Keravis, T., Yougbaré, I., Bronner, C., and Lugnier, C. (2011b). Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1. Mol Nutr Food Res 55, 1677–1689.

Alhosin, M., Sharif, T., Mousli, M., Etienne-Selloum, N., Fuhrmann, G., Schini-Kerth, V.B., and Bronner, C. (2011). Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties. J Exp Clin Cancer Res 30, 41.

Andersson, D.A., Gentry, C., Alenmyr, L., Killander, D., Lewis, S.E., Andersson, A., Bucher, B., Galzi, J.-L., Sterner, O., Bevan, S., et al. (2011). TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid             Δ(9)-tetrahydrocannabiorcol. Nat Commun 2, 551.

Bihel, F.J.J., Justiniano, H., Schmitt, M., Hellal, M., Ibrahim, M.A., Lugnier, C., and Bourguignon, J.-J. (2011). New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam. Bioorg Med Chem Lett 21, 6567–6572.

Choucair-Jaafar, N., Laporte, V., Levy, R., Poindron, P., Lombard, Y., and Gies, J.-P. (2011). Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides. Fundam Clin Pharmacol 25, 115–122.

Deramaudt, T.B., Dujardin, D., Hamadi, A., Noulet, F., Kolli, K., De Mey, J., Takeda, K., and Rondé, P. (2011). FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion. Mol Biol Cell 22, 964–975.

Lecat, S., Ouédraogo, M., Cherrier, T., Noulet, F., Rondé, P., Glasser, N., Galzi, J.-L., Mely, Y., Takeda, K., and Bucher, B. (2011). Contribution of a tyrosine-based motif to cellular trafficking of wild-type and truncated NPY Y(1) receptors. Cell Signal 23, 228–238.

Lugnier, C. (2011). PDE inhibitors: a new approach to treat metabolic syndrome? Curr Opin Pharmacol 11, 698–706.

Sick, E., Boukhari, A., Deramaudt, T., Rondé, P., Bucher, B., André, P., Gies, J.-P., and Takeda, K. (2011). Activation of CD47 receptors causes proliferation of human astrocytoma but not normal astrocytes via an Akt-dependent pathway. Glia 59, 308–319.

Vivot, K., Langlois, A., Jeandidier, N., Bietiger, W., Pinget, M., Gies, J.P., and Sigrist, S. (2011). Instant blood-mediated inflammatory reaction during islet transplantation: the role of Toll-like receptors signaling pathways. Transplant Proc 43, 3192–3194.

Woldt, E., Matz, R.L., Terrand, J., Mlih, M., Gracia, C., Foppolo, S., Martin, S., Bruban, V., Ji, J., Velot, E., et al. (2011). Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor. J Biol Chem 286, 16775–16782.

 Yougbare, I., Morin, C., Senouvo, F.Y., Sirois, C., Albadine, R., Lugnier, C., and Rousseau, E. (2011). NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues. Am J Physiol Lung Cell Mol Physiol 301, L441-450.