The group of A. Klymchenko “Nanochemistry and Bioimaging” developed DNA-functionalized fluorescent polymeric nanoparticles for amplified detection of nucleic acid cancer markers. These nanoparticles are 100-fold brighter than quantum dots and change their color in response to <10 hybridizations per particle. The work was published in J. Am. Chem. Soc.
Reference :
Melnychuk, N. ; Klymchenko, A.S. DNA-Functionalized Dye-Loaded Polymeric Nanoparticles : Ultrabright FRET Platform for Amplified Detection of Nucleic Acids, J. Am. Chem. Soc. 2018, 2018, 140, 10856.
https://pubs.acs.org/doi/10.1021/jacs.8b05840
